In addition, in vivo studies of a subcutaneous xenograft model of neuroblastoma in nude mice showed that 7×2b CAR-T cells effectively cleared tumors in mice, and also secreted a large number of human IFN-γ, IL-2, and GZMS-B, suggesting 7×2b CAR-T cells have a powerful anti-tumor effect. This evidence concerns the gene IL2 and neoplasm.