IFNG and neoplasm: By co-culturing 7×2b CAR-T cells, T cells, and CAR-T cells with GD2-positive tumor cells (A375, C32, Malme-3M, and IMR-32), we found that both classical and 7×2b CAR-T cells secreted a significant amount of IFN-γ, while the GD2-negative tumor cells (SK-MEL-3 and SK-N-SH) could hardly induce the release of IFN-γ (Figure 2B).