A preclinical study showed that PARPi’s plus DNMT inhibitors (DNMTi’s, 5-azacytidine/AZA, decitabine/DAC) increased PARPi efficacy and resulted in additional tumor inhibition in TNBC cells harboring wild-type BRCA1 compared with each drug alone (32). This evidence concerns the gene BRCA1 and neoplasm.