ERBB2 and neoplasm: Supplementary Table S2 presents the primary features of these studies, including the study phase, study size, tumor stage, treatment, pCR rate, and pCR definition. Neoadjuvant therapies typically involved anthracycline–taxane combined with HER2-targeted drugs. The main HER2-targeted drugs were trastuzumab, pertuzumab, lapatinib, and T-DM1, which were used as single or dual HER2 blockades. The results of the quality assessment are presented in Figure 2 (quality assessment results for each study are presented in Supplementary Figure S1).