Additionally, several specific gene-drug associations in gastric cancer PDOs were discovered in other studies, including tumor organoids with ErbB2-amplification exhibiting high sensitivity to lapatinib (65) and AKT1-amplified gastric cancer organoids showing exquisite responses to anti-AKT antibodies (MK-2206 and GSK690693) (52, 66). Here, AKT1 is linked to gastric cancer.