CD274 and cancer: The results from the KEGG pathway enrichment analysis indicated that these 291 upregulated DEGs were mapped to the proteoglycans in cancer, and molecules involved in axon guidance, cell adhesion, extracellular matrix-receptor interaction, and the TGF-β signaling pathway, and that these 106 downregulated DEGs were mapped to molecules involved in primary immunodeficiency, hematopoietic cell lineage, the T cell receptor signaling pathway, Th17 cell differentiation, PD-L1 expression, the PD-1 checkpoint pathway in cancer, Th1 and Th2 cells differentiation, et al.