Multiple theories were postulated to explain the pathogenesis of hepatic changes such as ACE2-mediated direct hepatocyte viral invasion, disrupted immune homeostasis, systemic inflammatory response, concurrent hypotension, pneumonia-associated hypoxia, cytokine storm with a surge of the pro-inflammatory cytokines, and drug-induced hepatotoxicity [13, 14]. The gene discussed is ACE2; the disease is susceptibility to pneumonia measurement.