Interleukin-6 (IL-6), which is produced in large amounts in patients with severe COVID-19 and is considered a primary factor in triggering cytokine storm, is correlated with increased inflammatory activity (systemic inflammatory response, respiratory distress syndrome-induced hypoxia, or multiple organ dysfunction) in patients, particularly those with obesity [27, 28]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.