It is noteworthy that the platelet count is a convenient marker of liver fibrosis in several hepatic diseases, such as nonalcoholic fatty liver disease, hepatitis B and C; nevertheless, there are studies reporting conflicting results as thrombocytopenia is valuable marker of advanced liver disease and combined assessment of the AST/ALT ratio and platelet had a high diagnostic value for cirrhosis [16]. This evidence concerns the gene GPT and Hepatic fibrosis.