A statistically significant increase in serum GDF-15 levels was noticed among patients with advanced fibrosis (subgroup ІІІ) compared to those with mild fibrosis (subgroup І), while there was no significant difference in the GDF-15 level among patient subgroups І and Ц and between patient subgroups Ц and ІІІ. This evidence concerns the gene GDF15 and fibrosis.