A series of subsequent clinical studies have shown that FGF21 binds to FGFR1 in the form of autocrine or paracrine in the heart [9, 37], which can be used as a predictor of cardiovascular diseases such as acute myocardial infarction and coronary heart disease and play a potential role in prevention and rehabilitation of cardiovascular diseases [38–41]. Here, FGF21 is linked to coronary artery disorder.