As expected, CIH induced cardiac hypertrophy as evaluated by the heart weight/body weight ratio (Figure 1(b), ∗∗∗∗p < 0.0001 vs. Ctrl), which was significantly attenuated in the SRC-3 KO mice (Figure 1(b), ∗p < 0.05vs. CIH). This evidence concerns the gene NCOA3 and cardiac hypertrophy.