PACC1 and neoplasm: As shown in Figure 1(d), although all OS cell lines expressed more TMEM206 than the human fetal osteoblastic cell line hFOB1.19, interestingly, expression of TMEM206 was more apparent in lines with higher xenogenic tumor growth potential, such as MG 63, compared to lines with less tumorigenic capacity, such as SaOS2 (Figure 1(d), P < 0.01).