IL6 and pancreatic adenocarcinoma: Since studies have shown that Th2 cells suppress the antitumor immune response by producing various kinds of cytokines, such as interleukin 6 (IL6) and interleukin 10 (IL10) [35, 36], we further analyzed the relationship of BDNF with IL6 and IL10 expressions in PAAD and found that BDNF was positively associated with IL6 (r = 0.36, p < 0.01, Figure 5(b)) and IL10 (r = 0.32, p < 0.01, Figure 5(b)).