Thus, this study is broadly aimed at studying the mechanisms underpinning the oncogenic role of BDNF in PAAD by combining available information from several public databases, including Cancer Cell Line Encyclopedia (CCLE), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Genotype-Tissue Expression (GTEx), International Cancer Genome Consortium (ICGC), Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis (GEPIA), and Kaplan-Meier plotter. This evidence concerns the gene BDNF and pancreatic adenocarcinoma.