Previous literature revealed that the upregulation of TGFB2 expression can mediate epithelial-mesenchymal transition of pancreatic ductal adenocarcinoma, and MET, IRS1, and BCL2L1 are also demonstrated to be related to PAAD initiation, progression, and metastasis [44–46]. The gene discussed is IRS1; the disease is pancreatic adenocarcinoma.