In this study, univariable COX regressive assay for the survival of GC sufferers was completed to identify the important factors within 760 DEGs, and we identified 26 prognostic genes, including OMD, ABCA6, RGS1, MEOX2, MCEMP1, ZEB2, ABCA9, SVEP1, PLXDC2, VGLL3, ASPA, DCN, GGT5, FMO1, CCDC80, FLRT2, ABCA8, CDO1, CFH, BPI, COLEC12, CD36, FGF7, FAM216B, OGN, and CXCR4. This evidence concerns the gene VGLL3 and gastric cancer.