For example, the expression of galectin-3 in serum and saliva in patients with periodontitis and periodontitis + coronary heart disease is significantly higher than that in patients with coronary heart disease and healthy controls, indicating that galectin-3 in the serum and saliva may be used as a marker for predicting periodontitis and periodontitis and coronary heart disease [20]. The gene discussed is LGALS3; the disease is coronary artery disorder.