We found that CYP7A1, GINS2, and PDLIM3 were significantly up-regulated, and MYC, MAMDC4, ADAMTS1, THBS1, and RASD1 were significantly down-regulated in HCC tumor samples compared with normal samples using the TCGA dataset (Figure 6A). This evidence concerns the gene MAMDC4 and hepatocellular carcinoma.