Integrating the results of two steps of survival analyses, high expression of HMGBs suggested unfavorable prognosis in the following cancers: HMGB1 in ACC; HMGB2 in ACC, KIRP, LGG, LIHC, MESO; and HMGB3 in BRCA, ESCA, SARC, and SKCM. Here, HMGB1 is linked to cancer.