As for the TMB, HMGB1/2/3 expression was significantly positively correlated with the TMB of 4 (12.1%), 11 (33.3%), and 16 (48.5%) kinds of cancers but negatively correlated with the TMB of 4 (12.1%), 2 (6.0%), and 2 (6.0%) kinds of cancers, respectively (Figures 6D–F). Here, HMGB1 is linked to cancer.