Besides, significant positive correlations between the expression of HMGBs and ICP genes were found in the following cancers: HMGB1 in HNSC, LIHC, PAAD, and PRAD and HMGB2 in HNSC, KIRC, KIRP, LGG, LIHC, PRAD, THCA, and SKCM. The gene discussed is HMGB1; the disease is cancer.