HMGB1 and cancer: Among 33 kinds of cancers, HMGB1/2/3 expression was significantly positively correlated with the MSI of 6 (18.2%), 10 (30.3%), and 10 (30.3%) types of cancers but negatively correlated with the MSI of 2 (6.0%), 1 (3.0%), and 1 (3.0%) types of cancers respectively (Figures 6A–C).