In addition, elevated HMGB expression indicated clinicopathological advances in these cancers: HMGB1 in ACC, HNSC, and ESCA; HMGB2 in ACC, HNSC, KIRC, LGG, and LIHC; and HMGB3 in ESCA and HNSC. The gene discussed is HMGB2; the disease is cancer.