HMGB3 was upregulated in 11 other types of cancers, including breast invasive carcinoma (BRCA), esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), ovarian serous cystadenocarcinoma (OV), prostate adenocarcinoma (PRAD), testicular germ cell tumors (TGCT), and uterine corpus endometrial carcinoma (UCEC). The gene discussed is HMGB3; the disease is head and neck squamous cell carcinoma.