We found that a higher expression of HMGB1 was significantly related with worse OS of patients with ACC (HR = 2.36, p = 0.043) and KICH (HR = 4.75 p = 0.037), whereas a better OS of patients with THYM was found (HR = 0.11, p = 0.011) (Figure 2A). Here, HMGB1 is linked to adrenal cortex carcinoma.