In detail, HMGB1/2/3 was uniformly up-expressed in eight kinds of cancers, including colon adenocarcinoma (COAD), lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), glioblastoma multiforme (GBM), brain lower grade glioma (LGG), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and thymoma (THYM). Here, HMGB1 is linked to gastric adenocarcinoma.