The cytosolic transport (RNF126, PLEKHJ1, VPS51, and AP1G1), target of rapamycin (mTOR) signaling (PIK3CA, STK11, RPS6KB2, and PRR5), regulation of translation, metabolic regulation, and apoptosis are involved in the percent emphysema-associated network. Here, RPS6KB2 is linked to pulmonary emphysema.