The FEV1pp miRNA–mRNA networks and percent emphysema network share three genes (CAPZA1, CEP57, and SLC15A3) and eight miRNAs including hsa-miR-145-5p, hsa-miR-223-3p, hsa-miR-26b-3p, hsa-miR-338-5p, hsa-miR-1275, hsa-miR-150-3p, hsa-miR-150-5p, and hsa-miR-342-3p. The gene discussed is SLC15A3; the disease is pulmonary emphysema.