In esophageal squamous cell carcinoma (ESCC), lncRNA NMR methylated by NSUN2 combines with the chromatin regulator BPTF to promote the expression of MMP3 and MMP10 via the ERK1/2 pathway; thus, promoting the progression of ESCC (Li Y. et al., 2018). The gene discussed is MAPK3; the disease is esophageal squamous cell carcinoma.