By comparing the clinical features in the SPD patients with different HOXD13 mutations (PolyA, homeobox, and non-homeobox), we found a statistically significant difference in the severity scores between polyA mutation and homeobox or non-homeobox (P < 0.05) although no significant difference was observed between the variants in homeobox and non-homeobox (Figure 3D). This evidence concerns the gene HOXD13 and Platelet storage pool disease.