CXCL9, CXCL10, CXCL11/CXCR3 axis has been proved to regulate immune cell migration, differentiation, and activation (Tokunaga et al., 2018; Neo et al., 2020), leading to tumor suppression in pancreatic adenocarcinoma, colorectal cancer and so on (Gao et al., 2020). This evidence concerns the gene CXCR3 and pancreatic adenocarcinoma.