For instance, based on the report that lncRNA H2K2 promoted diabetic nephropathy progression via the miR-449a/b/Trim11/Mek signaling pathway (Chen et al., 2019), we inferred that dysregulated H2K2 in RD mice may partially mediate retinal disease progression via the competitive endogenous RNA (ceRNA) mechanism, in which lncRNAs may compete with protein-coding mRNAs for binding to miRNAs. This evidence concerns the gene TRIM11 and diabetic kidney disease.