NPM1 and acute myeloid leukemia: To explore the independent prognostic factors for AML, univariate and multivariate Cox analyses were sequentially performed in the BEATAML1.0 dataset (Figure 8A), including the hypoxia risk score and other available clinical characteristics, such as age, gender, ELN 2017, the mutations of NPM1 and FLT3, and CEBPA Biallelic status.