A total of 33 genes (ALDH1A1, ALDOC, BACE2, BATF3, CA9, CALD1, COL5A1, DR1, EGLN3, ELOB, HBP1, HK1, ID2, KRT14, LRP8, NOS1, NOS2, PDK3, PLOD2, PSMA2, PSMA7, PSMB6, PSMC1, PSMC4, PTGS1, RPS27A, SIAH2, SLC16A1, SORL1, TGM2, THBS1, TPD52, and UBA52) were identified to have a significant prognostic value in patients with AML (p < 0.05). The gene discussed is HK1; the disease is acute myeloid leukemia.