THBS1 and acute myeloid leukemia: Furthermore, Lidan et al. have found that THBS1 was lowly expressed in AML patients, which may be induced by promoter methylation, and patients with low THBS1 expression had a shorter survival time; furthermore, Allogeneic Hematopoietic Stem Cell transplantation can overcome the adverse effects mediated by low THBS1 expression (Zhu et al., 2019).