MYC and acute myeloid leukemia: However, in recent years, it has also been found that knockdown of lncRNA UCA1 induced apoptosis and inhibited the proliferation in AML cells (U937 and HL60), indicating lncRNA UCA1 could meditate the AML process by regulating the miR-296–3p/Myc axis (Li J. J. et al., 2020).