This result coincides with previous studies reporting that HGF may indirectly affect the prognosis of AML patients, whereas the prognostic effect of HGF was no longer significant after adjusting for the effects of certain factors in multivariate analysis, which likewise provides a possibility for related studies to further elucidate the combination of cytokines associated with HGF and thus reveal the development of AML (Fuhrmann-Benzakein et al., 2000). Here, HGF is linked to acute myeloid leukemia.