Besides, the results of multivariate Cox regression analysis showed that the critical mRNAs ADCY1, CCL5 are selected as risk factors affecting the prognosis of AML patients, but CXCR6 and COL6A2 are showed as protective factors in AML (p <0.05) (Figure 6B). The gene discussed is CXCR6; the disease is acute myeloid leukemia.