Therefore, we have independently expanded the interactions of these two genes based on the previous finding and propose that the three potential interactions regulatory networks: lncRNA UCA1/hsa-miR-16–5p/COL4A5, lncRNA UCA1/hsa-miR-16–5p/SPARC, and lncRNA SNORA27/hsa-miR-17–5p/CCL5 may play an essential role in AML. The gene discussed is UCA1; the disease is acute myeloid leukemia.