Firstly, we examined 49 DE-FLs in CRC by analyzing TCGA-COADREAD data set (Smyth, 2004), then 4 DE-FLs (AC016027.1, AC099850.3, ELFN1-AS1, and VPS9D1-AS1) that significantly correlated with OS were found to construct the risk signature according to the univariate and multivariate Cox regression analysis. Here, VPS9D1 is linked to colorectal carcinoma.