Adiponectin is the most important adipocytokine, and its expression is inversely correlated to the amount of fat tissue in the body: In conditions of obesity and type 2 diabetes, it is downregulated, while it is up-regulated during starvation (Kadowaki et al., 2006; Lee and Shao, 2006). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.