Moreover, in cell cultures of human adipocytes, cyanidin 3-glucoside (C3G) positively regulated obesity and type 2 diabetes markers increasing adiponectin and down-regulating PAI-1 (Plasminogen Activator Inhibitor-1) and IL-6 (Interleukin-6; Tsuda et al., 2006). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.