CEACAM8 and neoplasm: Leukocyte composition analysis based on tissue segmentation revealed significantly higher percentages of helper T cells (CD45+CD3+CD8−Foxp3−), B cells (CD45+CD3−CD20+), and CD66b+ granulocytes (CD45+CD3/CD20/CD56−CD66b+) in the intratumoral stroma and a higher percentage of tumor-associated macrophages (TAM) (CD45+CD3/CD20/CD56−CD66b−Tyrptase−CD68+CSF1R+), particularly CD163− TAM, in tumor cell nests (Figure 2A).