There was no significant impact of tumor cell nest or intratumoral stromal cell densities of TH1, TH2, CD8+ T cells (CD45+CD3+CD8+), and regulatory T cells (TREG) (CD45+CD3+CD8−Foxp3+) on overall survival (Figure 2D and Supplementary Figures 2B, C). Here, CD8A is linked to neoplasm.