C-reactive protein (CRP), interferon-γ (IFN-γ), interleukins (ILs) such as IL-1, IL-2, soluble IL-2 receptor alpha chain (IL-2Rα), IL-4, IL-6, IL-8, and IL-10, granulocyte-macrophage colony-stimulating factor (GM-CSF), granzyme B, and tumor necrosis factor-α (TNF-α) are among the most important mediators of CRS (27, 28). This evidence concerns the gene IL1B and congenital rubella syndrome.