In psoriasis, IL-17 activates epidermal KCs via IL-17R to produce proinflammatory cytokines and chemokines, such as IL-1, IL-6, CXCL1 (C-X-C motif), and CCL20 (C-C motif ligand 20) to induce and propagate psoriatic inflammation (17), while IL-23 drives a local skin inflammatory loop through IL-23 triggered production of IL-22, which in turn helps the maintenance of TH17 cells (18). The gene discussed is IL1B; the disease is psoriasis.