IL10 and Alzheimer disease: Besides, 42 significant dysregulated genes involving in epidermal differentiation (e.g., IL-10, KRT16, S100A8, and S100A9), antimicrobial, immunomodulatory chemokines (CXCL1, CXCL6), and negative regulation of T-cell activation (FOXK1) were found in chronic versus acute AD (22).