The importance of glycolysis as an mTOR target in the GvHD context is further highlighted by the observation that direct blockade of hypoxia-inducible factor 1-alpha (HIF1α), an important regulator of aerobic glycolysis downstream of mTOR, with echinomycin, effectively reduced acute GvHD while preserving GvT by reducing glucose-dependent Th1 and Th17 cells and promoting Treg induction (23). Here, MTOR is linked to graft versus host disease.