CTNNB1 and neoplasm: We found that the TIME of patients with CTNNB1-MUT is mainly one of immune depletion, which is reflected in the low proportion of activated immune cells, high proportion of depleted immune cells, low expression of immune stimulating molecules, low expression of immune checkpoint molecules, low activation of immunoactivation-related pathways, and high activation of tumor growth-promoting or drug resistance-related pathways.