It has been shown previously that monocyte-derived DC loaded with tumor antigens, derived from whole tumor cell lysates, are efficacious antigen-presenting cells able to initiate a T cell response against malignant glioma tumor cells showed by the upregulation of CD25 on CD8+ T cells and by the generation of cytotoxicity against the target cells (39). Here, CD8A is linked to malignant glioma.