Within this context, we observed a trend to increased TNF-α, IFN-α-2a and IFN-λ1 secretion as well as an increased expression of CD80, PD-L1 and HLA-ABC by the BDCA-1+/BDCA-3+ myDC after treatment with supernatant from T-VEC treated melanoma cells. This evidence concerns the gene IFNL1 and melanoma.