Additionally, GO and KEGG analyses were performed to analyze the top 200 down-regulated genes, which indicated the potential function of PMEPA1. The results also showed a strong association with cancer invasion and TME, which included 48 GO terms of BP, 10 GO terms of CC, 16 GO terms of MF, 91 GO terms of Immune System Process (ISP) and 16 pathways of KEGG (Table S9, Figures 2C and S3). The gene discussed is PMEPA1; the disease is cancer.