This study has attempted to elucidate the dynamic immunological parameter landscape, including both the number and function of innate (neutrophils, NK cells, monocytes, and lymphoid-derived DCs), adaptive (CD4+ and CD8+ T cells), and humoral (B cells, plasma cells, and antigen-specific IgG) immune cells, in COVID-19 patients with different outcomes. The gene discussed is CD8A; the disease is COVID-19.