These results also suggested a functional role of the LINC02549rs7767069 SNP in RA likely through the CD5/CD6-mediated modulation of T cells and certain subsets of B cells that control multiple processes including cellular adhesion and migration across endothelial and epithelial cells, antigen presentation by B cells and the subsequent proliferation of T cells. The gene discussed is CD6; the disease is rheumatoid arthritis.