TNF and rheumatoid arthritis: Interestingly, the meta-analysis of our data with those from the DREAM registry including 2067 RA patients confirmed the RF-specific effect of this SNP to modulate the response to anti-TNF drugs (per-allele ORMeta_RF+=0.67, 95%CI 0.54-0.84, PMeta=0.00058; PHet=0.06 and per-allele ORMeta_RF-=1.38, 95%CI 0.94-2.02, P=0.10; PHet=0.45; PInteraction=0.00028; Table 4).