Proteins of the Ras-signaling pathway were 0.5–0.64-fold downregulated upon virus infection, including three Rac GTPases Rac1-3 that are implicated in the regulation of cell morphology, migration and invasion, by transducing signals from cell surface receptors to the actin and microtubule cytoskeletons (Wheeler et al., 2006). Here, RAC1 is linked to viral infectious disease.