CD177 and viral infectious disease: Proteins of the Ras-signaling pathway were 0.5–0.64-fold downregulated upon virus infection, including three Rac GTPases Rac1-3 that are implicated in the regulation of cell morphology, migration and invasion, by transducing signals from cell surface receptors to the actin and microtubule cytoskeletons (Wheeler et al., 2006).