Further investigation of NASH-derived CD8 T and PD-1+ CD8 T cells at single-cell transcriptomic level revealed that the latter expressed higher levels of markers of effector function (TNFα, IFNγ, granzyme), exhaustion (Eomes, PD-1, Ki67low), and liver residency (CXCR6, CD44) (48). This evidence concerns the gene CXCR6 and metabolic dysfunction-associated steatohepatitis.