Moreover, a recent study using a choline-deficient, high-fat diet (CD-HFD) NASH mouse model showed that the number and frequency of iNKT cells did not change in NASH but Ja18- and CD1d-deficient mice that lack iNKT cells had more severe NASH comparable to wild-type controls (45). The gene discussed is CD1D; the disease is metabolic dysfunction-associated steatohepatitis.