Pathological analysis showed that bone OPG and RUNX 2 expression levels were lowered in type 1 diabetic rats (T1DM vs. Control, p < 0.01); RANKL level in bone tissue was higher in type 1 diabetic rats (T1DM vs. Control, p < 0.01) (Figure 9). Here, TNFSF11 is linked to type 1 diabetes mellitus.