INS and diabetes mellitus: The two cases (3.4%) of overt diabetes identified among the OT1D, and the higher 2-hour post-load glucose concentrations in the H-EPO group, are in line with previous studies in children (34), adolescents (36, 37) and adults (28, 44) demonstrating various degrees of derangement in glucose metabolism in OT1D, with elevated post-load PG and insulin concentrations being a typical finding.