WNK2 and leukoencephalopathy, megalencephalic: The modulator of VRAC current 1 (MLC1) is associated with Megalencephalic Leukoencephalopathy with subcortical cysts and it could be related to melanoma survival and chemoresistance through mitogen-activated protein kinases (MAPK) - extracellular signal-regulated kinases (ERK) pathway (30, 31).