IL6 and major depressive disorder: Our finding that effect of IL6 variation was only observable in those exposed to some forms of environmental influences, either early traumas or recent negative life events, falls in line with previous observations that in several psychiatric conditions, including depression (31, 52–55), genetic factors do not directly influence manifestations, but rather exert their effects via influencing sensitivity towards environmental factors, and it seems to be the case also for both suicide and inflammation.