Finally, although a combined effect of both VEGF164 and FGF2 was evaluated, Kovac et al. (2018) found significant improvements in ultrasonographic and clinical in eight out of 10 horses with the superficial digital flexor tendon and suspensory ligament branch lesions (in naturally occurring tendinitis and desmitis in horses) with gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes, returning to pre-injury level in 2–6 months. The gene discussed is FGF2; the disease is tendinitis.