Protective effects of atrial natriuretic peptide (ANP) against thrombin-induced MT disassembly and Rho-mediated endothelial dysfunction were also mediated by inhibitory phosphorylation of GEF-H1 by Rac1 GTPase effector, PAK1 kinase (Tian et al., 2014a). Here, ARHGEF2 is linked to endothelial dysfunction.