Use of angiotensin II (Ang II) was correlated with change in gut microbiome (Yang et al., 2015), oral administration of minocycline antibiotic reduced blood pressure presumably by altering the gut microbiome and fecal transplants from normotensive rats to stroke-prone SHR (SHRSP) reduced blood pressure (Adnan et al., 2017). Here, AGT is linked to Stroke.