TNC is highly expressed in such chronic lung diseases as COPD, bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS), IPF or asthma (Laitinen et al., 1997; Kaarteenaho-Wiik et al., 2002; Lofdahl et al., 2011; Estany et al., 2014; Yasuda et al., 2018). The gene discussed is TNC; the disease is newborn respiratory distress syndrome.