In this perspective, given the complexity of the mechanisms involved in the actions of physical exercise on renovascular hypertension-induced gastrointestinal tract dysmotility, it would be useful to investigate other biomarkers, such as the angiotensin (1–7) and ACE2, in the gastrointestinal tract, and the possible influence of mineralocorticoids, as well as to assess the nervous sympathetic activity in 2K1C rats, for a better understanding of such a relevant topic. Here, ACE2 is linked to renovascular hypertension.