LPL and osteoporosis: Zeng et al. (2016) analyzed the protein–RNA integration of monocytes from 33 white females, and the results revealed ITGA2B as a new gene related to osteoporosis. Lipoprotein lipase (LPL) is the key rate-limiting enzyme in triglyceride decomposition. Low estrogen levels hinder the activation of LPL, inhibit its fat decomposition function, and lead to the accumulation of fat. Ortmeyer et al. (2017) reported that aerobic exercise combined with diet can increase the LPL activity of the skeletal muscles and improve fatty acid metabolism in postmenopausal women.