For example, in the amelioration of diabetes, miR-129-3p decreases the apoptosis and recruitment of neutrophils by regulating the translation of Casp6 and Ccr2 (Umehara et al., 2019), whereas miR-129-5p inhibits ECM degradation by inhibiting the expression of Sp1-mediated MMP9 (Wang et al., 2018a). This evidence concerns the gene CASP6 and diabetes mellitus.