Mutation of the Tet2 (Tet methylcytosine dioxygenase 2) gene in hematopoietic stem cells or myeloid cells aggravated cardiac remodeling and function following pressure overload or cardiac ischemia; these effects were inhibited by a selective NLRP3 inflammasome inhibitor MCC950 (Sano et al., 2018). Here, TET2 is linked to myocardial ischemia.