Upon this condition, S-nitrosylation of muscle LIM protein (MLP) promoted the formation of a complex composed of toll-like receptor (TLR)3 and receptor-interacting protein kinase 3 (RIP3), which induced the activation of the NLRP3 inflammasome and IL-1β, resulting in the progression of myocardial hypertrophy. The gene discussed is IL1B; the disease is cardiac hypertrophy.