TLRs are among the major receptors responsible for the priming of the transcription of proinflammatory genes via the NF-κB pathway during acute myocardial infarction; extracellular ATP released from necrotic cells caused the triggering of NLRP3 inflammasomes via P2X7 (Toldo and Abbate, 2018). The gene discussed is P2RX7; the disease is myocardial infarction.