A number of actual mechanistic explanations have been advanced, for instance, Bostanci and collaborators analyzed—via an experimental model of periodontitis—the role of TREM-1 (Triggering receptor expressed on myeloid cells 1, a protein that amplifies inflammatory processes) as an over-expressed gene whose blockade inhibits IL-17A and RANKL transcription thus diminishing bone loss (Bostanci et al., 2019). Here, TREM1 is linked to periodontitis.