The relationship between PD and CVDs has been traced back to factors such as transfer of periodontal bacteria to atheromatous plaques, change of lipid metabolism (Ferguson et al., 2020), endothelial dysfunction, shared genetic risk factors, as well as pro-inflammatory cytokine (especially IL-6 and TNF-α) spillover in the bloodstream coming from periodontal tissues. Here, IL6 is linked to endothelial dysfunction.