In summary, we speculate that Guizhi Fuling Capsules may partially reduce the synthesis of arachidonic acid through the arachidonic acid metabolic pathway, and regulate the expression of COX-2 to reduce the production of downstream prostaglandins, thereby reducing the production of inflammatory mediators release to achieve the purpose of alleviating dysmenorrhea. The gene discussed is PTGS2; the disease is Dysmenorrhea.